| Seasonal variation in human central dopamine activity. | |
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MedLine Citation:
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PMID: 6584933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report focuses on two studies of seasonal variation of central dopamine activity in patients with schizophrenia and normal controls. In the two investigations, data were grouped and analyzed by season (i.e., spring-summer vs. fall-winter). The first study concerned blink rate, a putative measure of central dopamine activity; the blink rate for patients with schizophrenia was significantly increased during the spring-summer period. In the second study concentrations of catecholamines and their metabolites were measured in the hypothalamus and nucleus accumbens of normal and schizophrenic subjects. Findings include a reduced concentration of hypothalamus dopamine in normal controls and a reduced concentration of homovanillic acid in the nucleus accumbens of patients with schizophrenia, both during the spring-summer period. |
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Authors:
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C N Karson; K F Berman; J Kleinman; F Karoum |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Psychiatry research Volume: 11 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-05-24 Completed Date: 1984-05-24 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 111-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blinking Brain Chemistry* Dopamine / analysis* Female Homovanillic Acid / analysis Humans Hypothalamus / analysis Male Methoxyhydroxyphenylglycol / analysis Norepinephrine / analysis Nucleus Accumbens / analysis Schizophrenia / metabolism*, physiopathology Seasons* |
| Chemical | |
Reg. No./Substance:
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306-08-1/Homovanillic Acid; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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