Document Detail


Seasonal variation in assisted conception cycles and the influence of photoperiodism on outcome in in vitro fertilization cycles.
MedLine Citation:
PMID:  17190668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of seasonality and daylight length on mammalian reproduction leading to spring births has been well established, and is known as photoperiodism. In assisted reproduction there is much greater uncertainty as to the effect of seasonality. This was a 4-year retrospective analysis of 2709 standardised cycles of IVF/ICSI. Data was analysed with regard to the 1642 cycles occurring during the months of extended daylight (Apr-Sept) and those 1067 cycles during winter months of restricted light length (Oct-Mar). The results showed that there was significant improvement in assisted conception outcomes in cycles performed in summer (lighter) months with more efficient ovarian stimulation 766iu v880iu/per oocyte retrieved (p=0.006). There was similarly a significantly improved implantation rate per embryo transferred 11.42% vs 9.35% (p=0.011) and greater clinical pregnancy rate 20% vs 15% (p=0.0033) during summer cycles. This study appears to demonstrate a significant benefit of increased daylight length on outcomes of IVF/ICSI cycles. Whilst the exact mechanism of this is unclear, it would seem probable that melatonin may have actions at multiple sites and on multiple levels of the reproductive tract, and may exert a more profound effect on outcomes of assisted conception cycles than has been previously considered.
Authors:
Simon Wood; Alison Quinn; Stephen Troupe; Charles Kingsland; Iwan Lewis-Jones
Related Documents :
8006128 - Induction of pre-ovulatory luteinizing hormone surge by gonadotrophin-releasing hormone...
16478578 - Hmg versus rfsh for ovulation induction in developing countries: a cost-effectiveness a...
18441718 - Association between time from endometriosis surgery and outcome of in vitro fertilizati...
8574068 - In vitro fertilization: a cost-effective alternative for infertile couples?
4024878 - Correlation between 2,3-diphosphoglycerate and red cell mass in the third trimester of ...
21159788 - Increased vitamin e intake is associated with higher alpha-tocopherol concentration in ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human fertility (Cambridge, England)     Volume:  9     ISSN:  1464-7273     ISO Abbreviation:  Hum Fertil (Camb)     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-27     Completed Date:  2007-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888143     Medline TA:  Hum Fertil (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  223-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics & Gynaecology, Countess of Chester Hospital, Chester, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fertilization / physiology*,  radiation effects*
Fertilization in Vitro*
Humans
Photoperiod*
Seasons*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lesbian intra-partner oocyte donation: a possible shake-up in the Garden of Eden?
Next Document:  Research as a therapeutic experience? An investigation of women's participation in research on endin...