| Seasonal postpartum hypernatremic encephalopathy with osmotic extrapontine myelinolysis and rhabdomyolysis. | |
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MedLine Citation:
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PMID: 20129624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Neurological manifestations secondary to extrapontine myelinolysis and rhabdomyolysis caused by hypernatremia are infrequently reported. Occurrence of neurological manifestations due to spontaneous hypernatremia during postpartum period producing rhabdomyolysis and cerebral parenchymal MRI changes has not been previously reported. OBJECTIVE: Evaluation of clinical and radiological profile of postpartum hypernatremia. METHODS: Clinical, laboratory and radiological data of eleven women in postpartum period presenting with hypernatremic encephalopathy with or without muscle weakness were reviewed. RESULTS: Eleven puerperal women presented with encephalopathy due to hypernatremia from 2007 to 2009. Consciousness was altered in all the patients ranging from confusion to deep coma. Nine patients had quadriparesis, eight had corticospinal and corticobulbar dysfunction, six had ataxia, and seizures occurred in four patients. The patients had hypernatremia ranging from 158 to 199mEq/l with hyperchloremia, markedly elevated serum CK levels (2572 to 61,107U) and azotemia. Ten patients underwent MRI which revealed hyperintensity of corpus callosum in all the patients in T2, FLAIR and diffusion weighted sequences. Symmetrical hyperintensities were seen also in internal capsule, corona radiata, cerebellar peduncles and hippocampus in various combinations. Seven patients improved neurologically with reduction of serum sodium and CK levels while four patients died. CONCLUSION: Hypernatremia is a potentially lethal condition which can produce encephalopathy, osmotic demyelination and rhabdomyolysis. Prompt identification and appropriate management can improve the outcome in these patients. |
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Authors:
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Karkal Ravishankar Naik; Aralikatte O Saroja |
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Publication Detail:
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Type: Journal Article Date: 2010-02-02 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 291 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 5-11 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurology, Jawaharlal Nehru Medical College & KLES Dr. Prabhakar Kore Hospital and MRC, Nehrunagar, Belgaum, Karnataka 590010, India. krnaik60@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / pathology Brain Diseases / etiology*, mortality, pathology Cross-Sectional Studies Female Humans Hypernatremia / complications*, mortality, pathology Magnetic Resonance Imaging Muscle Weakness / complications, mortality, pathology Myelinolysis, Central Pontine / etiology*, mortality, pathology Postpartum Period* Retrospective Studies Rhabdomyolysis / etiology*, mortality, pathology Seasons* Young Adult |
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