Document Detail


Seasonal molecular timekeeping within the rat circadian clock.
MedLine Citation:
PMID:  15119947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In temperate zones duration of daylight, i.e. photoperiod, changes with the seasons. The changing photoperiod affects animal as well as human physiology. All mammals exhibit circadian rhythms and a circadian clock controlling the rhythms is located in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN consists of two parts differing morphologically and functionally, namely of the ventrolateral (VL) and the dorsomedial (DM). Many aspects of SCN-driven rhythmicity are affected by the photoperiod. The aim of the present overview is to summarize data about the effect of the photoperiod on the molecular timekeeping mechanism in the rat SCN, especially the effect on core clock genes, clock-controlled genes and clock-related genes expression. The summarized data indicate that the photoperiod affects i) clock-driven rhythm in photoinduction of c-fos gene and its protein product within the VL SCN, ii) clock-driven spontaneous rhythms in clock-controlled, i.e. arginine-vasopressin, and in clock-related, i.e. c-fos, gene expression within the DM SCN, and iii) the core clockwork mechanism within the rat SCN. Hence, the whole central timekeeping mechanism within the rat circadian clock measures not only the daytime but also the time of the year, i.e. the actual season.
Authors:
A Sumová; Z Bendová; M Sládek; Z Kováciková; H Illnerová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  53 Suppl 1     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-03     Completed Date:  2005-04-19     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S167-76     Citation Subset:  IM    
Affiliation:
Department of Neurohumoral Regulations, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. sumova@biomed.cas.cz
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Clocks / genetics,  physiology*
Circadian Rhythm / genetics,  physiology*
Gene Expression Regulation
Photoperiod
Rats
Seasons
Suprachiasmatic Nucleus / physiology*
Time Factors

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