Document Detail

Seasonal fluctuation in birthweight in schizophrenia.
MedLine Citation:
PMID:  12223246     Owner:  NLM     Status:  MEDLINE    
The birthweights of 450 schizophrenic patients born in 1971-1978 were compared with those of individually matched controls from the same birth cohort. Schizophrenics born in the second quarter of the year (April to June) had a significantly lower birthweight than their controls and this was not attributable to differences in the duration of gestation. Analogous proband/control differences were not found in 301 patients with affective psychoses, but there was a similar, much smaller, seasonal fluctuation in birthweight in the general population. These findings may be a clue both to the genesis of the "season of birth effect" and to the identity of the intrauterine influences contributing to the aetiology of schizophrenia. Folate deficiency may be implicated.
R E Kendell; J H Boyd; V L Grossmith; M Bain Bain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Schizophrenia research     Volume:  57     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-11     Completed Date:  2002-11-08     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM    
Department of Psychiatry and the Information and Statistics Division of the Scottish National Health Service, Edinburgh University, UK.
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MeSH Terms
Birth Weight*
Case-Control Studies
Infant, Newborn
Linear Models
Matched-Pair Analysis
Multivariate Analysis
Schizophrenia / epidemiology*
Scotland / epidemiology

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