| Seasonal affective disorder. | |
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MedLine Citation:
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PMID: 9802288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seasonal affective disorder (SAD) is a form of recurrent depressive or bipolar disorder, with episodes that vary in severity. Seasonal patterns of depressive episodes are common, but SAD seems to be less common than such patterns suggest. SAD was at first believed to be related to abnormal melatonin metabolism, but later findings did not support this hypothesis. Studies of brain serotonin function support the hypothesis of disturbed activity. The short-allele polymorphism for serotonin transporter is more common in patients with SAD than in healthy people. Atypical depressive symptoms commonly precede impaired functioning, and somatic symptoms are frequently the presenting complaint at visits to family physicians. The best treatment regimens include 2500 Ix of artificial light exposure in the morning. When patients seem to have no response or to prefer another treatment, antidepressants should be considered. |
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Authors:
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T Partonen; J Lönnqvist |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Lancet Volume: 352 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1998-11-17 Completed Date: 1998-11-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1369-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, University of Helsinki, National Public Health Institute, Finland. timo.partonen@ktl.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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metabolism Female Humans Male Melatonin / metabolism Phototherapy* Seasonal Affective Disorder* / diagnosis, epidemiology, genetics, therapy Serotonin / metabolism |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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