Document Detail

Seasonal affective disorder.
MedLine Citation:
PMID:  9802288     Owner:  NLM     Status:  MEDLINE    
Seasonal affective disorder (SAD) is a form of recurrent depressive or bipolar disorder, with episodes that vary in severity. Seasonal patterns of depressive episodes are common, but SAD seems to be less common than such patterns suggest. SAD was at first believed to be related to abnormal melatonin metabolism, but later findings did not support this hypothesis. Studies of brain serotonin function support the hypothesis of disturbed activity. The short-allele polymorphism for serotonin transporter is more common in patients with SAD than in healthy people. Atypical depressive symptoms commonly precede impaired functioning, and somatic symptoms are frequently the presenting complaint at visits to family physicians. The best treatment regimens include 2500 Ix of artificial light exposure in the morning. When patients seem to have no response or to prefer another treatment, antidepressants should be considered.
T Partonen; J Lönnqvist
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lancet     Volume:  352     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-17     Completed Date:  1998-11-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1369-74     Citation Subset:  AIM; IM    
Department of Psychiatry, University of Helsinki, National Public Health Institute, Finland.
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MeSH Terms
Brain / metabolism
Melatonin / metabolism
Seasonal Affective Disorder* / diagnosis,  epidemiology,  genetics,  therapy
Serotonin / metabolism
Reg. No./Substance:
50-67-9/Serotonin; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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