Document Detail

Season and weather patterns at time of birth in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  22871076     Owner:  NLM     Status:  Publisher    
Studies in the northern hemisphere suggest that the numbers of amyotrophic lateral sclerosis (ALS) births vary depending on the season of the year. We wished to determine if a southern hemisphere study would show the same seasonal changes, and whether particular weather conditions were associated with the numbers of ALS births. Birth data from a case-control study of Australian residents were used to relate monthly birth rates of ALS to the seasons and weather conditions. The results were compared with previous studies in Japan, Sweden and Switzerland. Four hundred and ninety-one Australian sporadic ALS patients and 629 controls (partners, friends, and community volunteers) completed a self-reported questionnaire that included dates of birth. Australian ALS birth rates increased between late summer and early winter, and decreased between mid-winter and early summer. Similar patterns were seen in Japan and Sweden. Monthly average humidity correlated positively with the numbers of ALS births in Australia, Sweden, and Japan. In conclusion, seasonal differences in ALS birth rates in the southern hemisphere are similar to those in two out of three northern hemisphere countries. Early life factors related to weather conditions, such as increased humidity leading to more infectious diseases and allergens, need to be further investigated in ALS.
Roger Pamphlett; Fang Fang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-7
Journal Detail:
Title:  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases     Volume:  -     ISSN:  1471-180X     ISO Abbreviation:  Amyotroph Lateral Scler     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101283386     Medline TA:  Amyotroph Lateral Scler     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The Stacey Motor Neuron Disease Laboratory, Department of Pathology, The University of Sydney , Australia.
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