Document Detail

Season of the first trimester of pregnancy predicts sensitisation to food allergens in childhood: a population-based cohort study from Finland.
MedLine Citation:
PMID:  20959386     Owner:  NLM     Status:  In-Data-Review    
Objective To examine whether the season of birth or season of the early phase of gestation is associated with sensitisation to food allergens in children, with special reference to mothers' pollen exposure in spring. Design A population-based cohort study linking information from a questionnaire survey to allergy tests performed on the target population and regional pollen counts. Population Children born in 2001-6 who were resident in the province of South Karelia, Finland, at the time of the survey (N=5920). Main Outcome Measures A positive result in any food allergy test or food-specific immunoglobulin E test (sIgE). Results The cumulative incidence of a positive food allergy test up to the age of 4 years was highest among children born in October-November (10%) and lowest among those born in June-July (5%), and correspondingly highest among children who were in their 11th gestational week in April-May (11%), the season of high concentrations of birch and alder pollen, and lowest among those reaching that stage in December-January (6%). The amplitude of seasonal variation in any test, estimated as the relative ratio between the peak and trough of the smoothed incidence curve over the year, was 2.03 (95% CI 1.52 to 2.76). The amplitudes of positive sIgE were especially pronounced for milk (3.07; 95% CI 1.81 to 5.50) and egg (3.03; 95% CI 1.86 to 5.18). Conclusions Children having their early gestational period in the pollen season for broad-leafed trees are more prone to sensitisation to food allergens than other children.
Kaisa Pyrhönen; Esa Läärä; Liisa Hiltunen; Minna Kaila; Timo Hugg; Simo Näyhä
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Publication Detail:
Type:  Journal Article     Date:  2010-10-19
Journal Detail:
Title:  Journal of epidemiology and community health     Volume:  66     ISSN:  1470-2738     ISO Abbreviation:  J Epidemiol Community Health     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909766     Medline TA:  J Epidemiol Community Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
South Karelian Institute, Lappeenranta University of Technology, PO Box 20, FIN-53851 Lappeenranta, Finland;
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