Document Detail

Season of birth and lung fibrosis among workers exposed to asbestos.
MedLine Citation:
PMID:  17612950     Owner:  NLM     Status:  MEDLINE    
The season of birth has been suggested to influence the development of some diseases, but its role in lung fibrosis seems to not have been studied previously. The aim of this study was to investigate the relation between the season of birth and fibrotic abnormalities as detected radiologically in high-resolution computed tomography (HRCT) among workers exposed to asbestos. The HRCT examination was performed on 528 study subjects. Multiple ordinal regression analysis adjusting for covariates was used to study the relations between birth month or season and radiological fibrosis signs. Subjects born in autumn or winter had more extensive fibrotic changes than those born in spring or summer. This applied to all fibrotic changes, apart from subpleural nodules, but only the overall fibrosis score, septal lines, and honeycombing showed statistically significantly higher values in comparison to spring births. The highest scores were detected among those born in autumn and winter months (September-February). These results suggest that there are differences in fibrotic radiological abnormalities according to the season of birth in adults exposed to asbestos. Several hypotheses could explain the observed findings, including the effects of early respiratory infections, cold temperature, and differences in air pollution levels, as well as some metabolic and hormonal effects.
Timo Hannu; Maritta S Jaakkola; Leena Kivisaari; Matti S Huuskonen; Tapio Vehmas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chronobiology international     Volume:  24     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-51     Citation Subset:  IM    
Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland.
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MeSH Terms
Age Factors
Aged, 80 and over
Asbestos / poisoning*
Asbestosis / etiology,  pathology
Body Mass Index
Environmental Exposure / adverse effects*
Lung / drug effects,  pathology
Middle Aged
Occupational Diseases / etiology,  pathology*
Pulmonary Fibrosis / etiology,  pathology*
Sex Factors
Smoking / adverse effects
Tomography, Spiral Computed
Reg. No./Substance:
0/Carcinogens; 1332-21-4/Asbestos

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