| Searching for osteoporosis genes in the post-genome era: progress and challenges. | |
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MedLine Citation:
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PMID: 12904838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Osteoporosis is a common skeletal disease characterized by low bone mineral density (BMD), deterioration of bone microarchitecture and increased fracture risk. It is a complex disease that has high social and economic costs. Osteoporosis and its associated phenotypes are under the strong genetic control. Identification and characterization of specific loci or genes involved in determining osteoporosis and its associated phenotypes will contribute to a greater understanding of the pathogenesis of osteoporosis, and ultimately might lead to the development of better diagnosis, prevention and treatment strategies. Efforts to identify osteoporosis genes have focused on three approaches: animal models, candidate gene approach, and genome-wide scans. In this article, we review the current status for mapping and identification of genes for osteoporosis, with a focus on some promising regions and future prospects. |
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Authors:
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Qing-Yang Huang; Robert R Recker; Hong-Wen Deng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review Date: 2003-08-05 |
Journal Detail:
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Title: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Volume: 14 ISSN: 0937-941X ISO Abbreviation: Osteoporos Int Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-11-11 Completed Date: 2003-12-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9100105 Medline TA: Osteoporos Int Country: England |
Other Details:
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Languages: eng Pagination: 701-15 Citation Subset: IM |
Affiliation:
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College of Life Sciences, Hunan Normal University, 410081 ChangSha, Hunan, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Density / genetics Genetic Predisposition to Disease* Genome, Human Humans Linkage (Genetics) Osteoporosis / genetics* Quantitative Trait Loci |
| Grant Support | |
ID/Acronym/Agency:
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K01 AR02170-01/AR/NIAMS NIH HHS; P01 DC01813-07/DC/NIDCD NIH HHS; R01 AR45349-01/AR/NIAMS NIH HHS; R01 GM60402-01 A1/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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