Document Detail


Searching for neuropathology: gliosis in schizophrenia.
MedLine Citation:
PMID:  21035789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neuropathology of schizophrenia remains elusive. One indication of this elusiveness is that the literature, in contrast to that on the neuropathology of almost any other disease, deals predominantly with measures of normal structures rather than with the demonstration and characterization of pathological structures. An important exception to this trend has been the continued search, over four decades, for reactive glia. In this article, we review histological and radiological evidence for and against astrocytosis and microgliosis specifically associated with schizophrenia. The studies are generally limited by small samples, flawed designs, and potentially biased methods of counting cells. Interpretation of these studies is further complicated by the frequent presence of glial reactions in older individuals without psychiatric disease. Nonetheless, some of the positive findings in the literature cannot easily be dismissed. A sufficiently large autopsy study, weighted toward younger subjects, could provide a definitive answer, which if positive could be a major step toward finding an underlying pathological process.
Authors:
Tatiana P Schnieder; Andrew J Dwork
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-30
Journal Detail:
Title:  Biological psychiatry     Volume:  69     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-04-19     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Astrocytes / pathology*
Autopsy
Brain / pathology*,  physiopathology
Gliosis / complications,  pathology*
Humans
Microglia / pathology*
Neuropsychiatry / methods
Postmortem Changes
Schizophrenia / complications,  pathology*
Grant Support
ID/Acronym/Agency:
MH60877/MH/NIMH NIH HHS; MH64168/MH/NIMH NIH HHS; R01 MH060877/MH/NIMH NIH HHS; R01 MH060877-12/MH/NIMH NIH HHS; R01 MH064168/MH/NIMH NIH HHS; R01 MH064168-07/MH/NIMH NIH HHS
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