Document Detail


Search for neuroblastoma loci: characterization of tumor cell lines that could facilitate their positional cloning.
MedLine Citation:
PMID:  9049829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Specific chromosomal aberrations might indicate the position of genes responsible for a particular disease. Neuroblastoma is characterized by frequent deletions and/or rearrangements of the subtelomeric 1p region which, accordingly, is believed to host one or more oncosuppressor gene(s) directly or indirectly involved in the development of this and other tumors. Identification of these genes could be facilitated if cell lines with well characterized interstitial deletions or reciprocal translocations could be available for application of positional cloning strategies. In the present report we present additional and novel molecular data on three well established neuroblastoma cell lines (NLF, NMB and NGP). In one of these we have identified two sites that might be good candidates for hosting oncosuppressor genes; one of these is flanked by the D1S47 and ENO1 loci while the other is distal to the A12M2 locus.
Authors:
M Romani; R Muresu; E V Volpi; C Rozzo; J M Marchi; I Casciano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  31     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-15     Completed Date:  1997-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Affiliation:
Istituto Nazionale per la Ricerca sul Cancro, IST, Porto Conte Research and Training Laboratories, Alghero, Italy.
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MeSH Terms
Descriptor/Qualifier:
Cloning, Molecular / methods*
Humans
In Situ Hybridization, Fluorescence
Neuroblastoma*
Translocation, Genetic*
Tumor Cells, Cultured / cytology,  physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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