Document Detail


Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions--a strategy in translational psychopharmacology.
MedLine Citation:
PMID:  16541245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Animal studies and studies of human aging have suggested that the serotonin 5-HT1A receptor may serve as a biomarker for cognitive functioning and a target for pharmacological treatment of cognitive deficits. OBJECTIVES: The purpose of this positron emission tomography (PET) study was to search for relationships between interindividual variability in serotonin 5-HT1A receptor binding potential (BP) and cognitive functioning. MATERIALS AND METHODS: Twenty-four male control subjects, age 20-55 years, were examined with [11C]WAY100635 PET and a battery of cognitive tests. 5-HT1A receptor binding potential were calculated for the raphe nuclei, the hippocampus and the neocortex. Correlation coefficients between BP and cognitive performance were obtained for each region. RESULTS: There was a severalfold of variability in 5-HT1A BP between individuals. We found no significant correlation between regional [11C]WAY100635 binding and cognitive performance. CONCLUSIONS: The results do not provide support for involvement of the 5-HT1A receptor in cognitive functioning in man and question the predictive validity of some currently used animal models in translational neuroscience.
Authors:
Jacqueline Borg; Bengt Andrée; Johan Lundberg; Christer Halldin; Lars Farde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-16
Journal Detail:
Title:  Psychopharmacology     Volume:  185     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  389-94     Citation Subset:  IM    
Affiliation:
Section of Psychiatry, Department of Clinical Neuroscience, Karolinska Institute, 17176 Stockholm, Sweden. jacqueline.borg@ki.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Cognition / physiology*
Hippocampus / metabolism,  radionuclide imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neocortex / metabolism,  radionuclide imaging
Positron-Emission Tomography
Prospective Studies
Psychological Tests
Raphe Nuclei / metabolism,  radionuclide imaging
Receptor, Serotonin, 5-HT1A / biosynthesis*
Chemical
Reg. No./Substance:
112692-38-3/Receptor, Serotonin, 5-HT1A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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