| Search for Chronic Beryllium Disease Among Sarcoidosis Patients in Ontario, Canada. | |
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MedLine Citation:
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PMID: 21400234 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chronic beryllium disease (CBD) is clinically similar to other granulomatous diseases such as sarcoidosis. It is often misdiagnosed if a thorough occupational history is not taken. When appropriate, a beryllium lymphocyte proliferation tests (BeLPT) need to be performed. We aimed to search for CBD among currently diagnosed pulmonary sarcoidosis patients and to identify the occupations and exposures in Ontario leading to CBD. Questionnaire items included work history and details of possible exposure to beryllium. Participants who provided a history of previous work with metals underwent BeLPTs and an ELISPOT on the basis of having a higher pretest probability of CBD. Among 121 sarcoid patients enrolled, 87 (72%) reported no known previous metal dust or fume exposure, while 34 (28%) had metal exposure, including 17 (14%) with beryllium exposure at work or home. However, none of these 34 who underwent testing had positive test results. Self-reported exposure to beryllium or metals was relatively common in these patients with clinical sarcoidosis, but CBD was not confirmed using blood assays in this population. |
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Authors:
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Marcos Ribeiro; Leandro G Fritscher; Ahmed M Al-Musaed; Meyer S Balter; Victor Hoffstein; Bruce D Mazer; Lisa A Maier; Gary M Liss; Susan M Tarlo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-13 |
Journal Detail:
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Title: Lung Volume: - ISSN: 1432-1750 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701875 Medline TA: Lung Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada, marcos.ribeiro@utoronto.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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