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Scrub Typhus-associated Severe Hemophagocytic Lymphohistiocytosis With Encephalomyelitis Leading to Permanent Sequelae: A Case Report and Review of the Literature.
MedLine Citation:
PMID:  22627574     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disorder. There have been a few reports on HLH secondary to scrub typhus in adults. Here, we describe the case of a 9-year-old Korean girl who presented with the typical findings of HLH. Despite adequate antirickettsial and HLH treatment, the neurological impairment worsened and remained. This is the first case report of severe neurological impairment resulting from the very rare association of HLH with scrub typhus. Therefore, in endemic areas, a high index of suspicion for scrub typhus is warranted in patients presenting with HLH.
Authors:
Dong Kyun Han; Hee Jo Baek; Myung-Geun Shin; Jin Woong Kim; Hoon Kook; Tai Ju Hwang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-22
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  -     ISSN:  1536-3678     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of *Pediatrics †Laboratory Medicine ‡Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, Chollanamdo, Korea.
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