| Screening of various phenolic acids and flavonoid derivatives for their anticholinesterase potential. | |
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MedLine Citation:
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PMID: 18274286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alzheimer's disease (AD), the most common form of dementia, is a neurodegenerative disease characterized by progressive cognitive deterioration together with declining activities of daily living and neuropsychiatric symptoms or behavioural changes. The oldest, on which most currently available drug therapies are based, is known as the "cholinergic hypothesis" and suggests that AD begins as a deficiency in the production of the neurotransmitter acetylcholine. Therefore, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors have gained a great popularity for the treatment of AD. In this study, we screened in vitro inhibitory activities of a number of phenolic acids (chlorogenic, caffeic, gallic, and quinic acids) as well as of various flavonoid derivatives (genistein, biochanin A, naringin, apigenin, quercetin, luteolin-7-O-rutinoside, kaempferol-3-O-galactoside, diosmin, silibinin, and silymarin) against AChE and BChE at 1 mg/ml concentration using a microplate-reader assay based on the Ellman method. Among them, only quercetin showed a substantial inhibition (76.2%) against AChE, while genistein (65.7%), luteolin-7-O-rutinoside (54.9%), and silibinin (51.4%) exerted a moderate inhibition on BChE. |
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Authors:
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Ilkay Orhan; Murat Kartal; Fatma Tosun; Bilge Sener |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zeitschrift für Naturforschung. C, Journal of biosciences Volume: 62 ISSN: 0939-5075 ISO Abbreviation: Z. Naturforsch., C, J. Biosci. Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2008-02-15 Completed Date: 2008-04-14 Revised Date: 2009-11-04 |
Medline Journal Info:
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Nlm Unique ID: 8912155 Medline TA: Z Naturforsch C Country: Germany |
Other Details:
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Languages: eng Pagination: 829-32 Citation Subset: IM |
Affiliation:
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Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey. iorhan@gazi.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Butyrylcholinesterase
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metabolism Caffeic Acids / pharmacology Chlorogenic Acid / pharmacology Cholinesterase Inhibitors / chemistry, pharmacology* Flavonoids / chemistry, pharmacology* Gallic Acid / pharmacology Hydroxybenzoic Acids / chemistry, pharmacology* Kinetics |
| Chemical | |
Reg. No./Substance:
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0/Caffeic Acids; 0/Cholinesterase Inhibitors; 0/Flavonoids; 0/Hydroxybenzoic Acids; 149-91-7/Gallic Acid; 29656-58-4/phenolic acid; 327-97-9/Chlorogenic Acid; 331-39-5/caffeic acid; EC 3.1.1.-/Butyrylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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