Document Detail

Screening and treatment for heritable thrombophilia in pregnancy failure: inconsistencies among UK early pregnancy units.
MedLine Citation:
PMID:  19036110     Owner:  NLM     Status:  MEDLINE    
The significance of heritable thrombophilia in pregnancy failure is controversial. We surveyed all UK Early Pregnancy Units and 70% responded. The majority test routinely for heritable thrombophilias; 80%, 76% and 88% undertook at least one screening test in late miscarriage, recurrent miscarriage and placental abruption, respectively. The range of thrombophilias sought is inconsistent: testing for proteins C and S deficiency and F5 R506Q (factor V Leiden) is most prevalent. Detection of heritable thrombophilia frequently leads to administration of antithrombotics in subsequent pregnancies. Thus, thrombophilia testing and use of antithrombotics are widespread in the UK despite controversies regarding the role of heritable thrombophilia in the pathogenesis of pregnancy complications, and the lack of robust evidence for the efficacy of antithrombotic therapy.
Gillian Norrie; Roy G Farquharson; Mike Greaves
Publication Detail:
Type:  Journal Article     Date:  2008-11-19
Journal Detail:
Title:  British journal of haematology     Volume:  144     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
School of Medicine and Dentistry, Aberdeen University, Aberdeen, UK.
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MeSH Terms
Abortion, Habitual / diagnosis*
Factor V
Great Britain
Obstetrics and Gynecology Department, Hospital
Pregnancy Complications, Hematologic / diagnosis*
Pregnancy Trimesters
Prenatal Diagnosis / methods,  standards*
Protein C Deficiency / diagnosis
Protein S Deficiency / diagnosis
Thrombophilia / diagnosis*
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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