Document Detail

Screening for thrombophilia and antithrombotic prophylaxis in pregnancy: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET).
MedLine Citation:
PMID:  19671474     Owner:  NLM     Status:  MEDLINE    
The term thrombophilia describes an increased tendency to develop thrombosis and many laboratory markers with different strengths of association with thrombosis have been identified. The main causes of maternal mortality and morbidity in developed countries is venous thromboembolism (VTE) and obstetric complications. During pregnancy and puerperium the risk for VTE increases due to hemostatic imbalance towards a prothrombotic state, and it is further increased in women carriers of thrombophilia; recent studies have also demonstrated an association between thrombophilia and obstetric complications. These complications are, therefore, considered potentially preventable with the prophylactic administration of anticoagulant drugs, although their efficacy is not proven by data from randomized controlled trials. After a systematic comprehensive literature review and using a rigorous methodology, the expert panel formulated recommendations regarding the usefulness of screening for thrombophilia in pregnancy to identify high-risk women and for the management of antithrombotic prophyalxis. When evidence is lacking, consensus-based recommendations are provided.
Federico Lussana; Francesco Dentali; Rosanna Abbate; Ernesto d'Aloja; Armando D'Angelo; Valerio De Stefano; Elena M Faioni; Elvira Grandone; Cristina Legnani; Ida Martinelli; Paolo Simioni; Daniela Tormene;
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Publication Detail:
Type:  Journal Article; Practice Guideline     Date:  2009-08-11
Journal Detail:
Title:  Thrombosis research     Volume:  124     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e19-25     Citation Subset:  IM    
Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo Dipartimento di Medicina, Chirurgia e Odontoiatria, Universit? di Milano.
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MeSH Terms
Anticoagulants / administration & dosage*
Pregnancy Complications, Hematologic / diagnosis*,  drug therapy*
Risk Factors
Thrombophilia / diagnosis*,  drug therapy*
Thrombosis / diagnosis,  drug therapy
Reg. No./Substance:

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