| Screening and surveillance recommendations for pediatric gastrointestinal polyposis syndromes. | |
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MedLine Citation:
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PMID: 19300132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inherited polyposis syndromes are relatively rare disorders in pediatric gastroenterology practice, even in busy academic settings. It is important, however, for pediatric gastroenterologists to be aware of the serious health risks for children and their families affected by these disorders. The diagnosis of a polyp syndrome is often made in the first or second decade of life, long before the risk of gastrointestinal neoplasia. Pediatric gastroenterologists must be prepared then to offer families predictive genetic screening as well as endoscopic surveillance when appropriately indicated. The current overview is designed to provide general guidelines and, whenever possible, evidence-based recommendations for genetic testing, endoscopic surveillance and other screening approaches for children with inherited gastrointestinal polyposis syndromes. In this presentation, the focus is on screening for neoplastic change and complications in the gastrointestinal tract. It is important to understand that extraintestinal cancers are frequent in some of these disorders and the reader is referred to other authoritative sources for additional information about comprehensive health screening outside the gastrointestinal system. |
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Authors:
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John Barnard |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 48 Suppl 2 ISSN: 1536-4801 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-20 Completed Date: 2009-07-29 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: S75-8 Citation Subset: IM |
Affiliation:
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Research Institute at Nationwide Children's Hospital, Department of Pediatrics, Ohio State University College of Medicine, Columbus, OH 43205, USA. john.barnard@nationwidechildrens.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenomatous Polyposis Coli
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complications,
diagnosis*,
genetics Child Colonoscopy Colorectal Neoplasms / genetics, prevention & control* Gastrointestinal Neoplasms / genetics, prevention & control* Genetic Predisposition to Disease Genetic Testing* Humans Intestinal Polyposis / complications, diagnosis*, genetics Peutz-Jeghers Syndrome / complications, diagnosis*, genetics Syndrome |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK059656-09/DK/NIDDK NIH HHS; R01DK059656/DK/NIDDK NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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