Document Detail

Screening for preeclampsia using first-trimester serum markers and uterine artery Doppler in nulliparous women.
MedLine Citation:
PMID:  20691410     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the screening accuracy of pregnancy hypertensive disorders by maternal serum biomarkers and uterine artery Doppler in the first trimester. STUDY DESIGN: Prospectively enrolled nulliparous women had uterine artery Doppler and serum measured at 11-13 weeks. Maternal characteristics, uterine artery Doppler, and serum placental biomarkers (pregnancy-associated plasma protein-A, Inhibin-A, placental protein 13, A disintegrin and metalloprotease 12, free β-hCG, placental growth factor) were recorded. RESULTS: Among 893 women, 20 (2.2%) had gestational hypertension developed and 40 (4.5%) had preeclampsia developed, including 9 (1.0%) early-onset preeclampsia and 16 (1.8%) severe preeclampsia. A combined screening model with clinical characteristics, pregnancy-associated plasma protein-A, Inhibin-A, and placental growth factor could detect 75% of early-onset preeclampsia at a 10% false-positive rate. After adjustment for clinical variables, uterine artery Doppler, placental protein 13, and A disintegrin and metalloprotease 12 did not improve the diagnostic accuracy. CONCLUSION: A combination of clinical characteristics and first-trimester maternal serum biomarkers (pregnancy-associated plasma protein-A, Inhibin-A, and placental growth factor) provides an accurate screening for early-onset preeclampsia in nulliparous women.
François Audibert; Isabelle Boucoiran; Na An; Nikolai Aleksandrov; Edgard Delvin; Emmanuel Bujold; Evelyne Rey
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-05
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2010-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  383.e1-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Mosby, Inc. All rights reserved.
Department of Obstetrics and Gynecology, CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Canada.
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MeSH Terms
ADAM Proteins / blood
Biological Markers / blood
Chorionic Gonadotropin, beta Subunit, Human / blood
Early Diagnosis
Inhibins / blood
Linear Models
Mass Screening
Membrane Proteins / blood
Pre-Eclampsia / blood,  diagnosis*
Pregnancy Proteins / blood
Pregnancy Trimester, First*
Pregnancy-Associated Plasma Protein-A / analysis
Prospective Studies
ROC Curve
Severity of Illness Index
Smoking / blood
Ultrasonography, Doppler
Uterine Artery / ultrasonography*
Grant Support
IHD82661//Canadian Institutes of Health Research
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Galectins; 0/LGALS13 protein, human; 0/Membrane Proteins; 0/Pregnancy Proteins; 0/inhibin A; 144589-93-5/placenta growth factor; 57285-09-3/Inhibins; EC 3.4.24.-/ADAM 12 protein; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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