Document Detail

Screening predicted coding regions in poxvirus genomes.
MedLine Citation:
PMID:  10872878     Owner:  NLM     Status:  MEDLINE    
The amino acid composition and pI values were calculated for the predicted proteins of a series of complete poxvirus genomes. Many of the vaccinia virus (strain Copenhagen) minor ORFs, thought not to be functional genes, were found to have significantly more or less of several amino acids than a set of the largest 150 vaccinia virus proteins. Very high isoelectric point (pI) values were also correlated with a group of the minor ORFs. Analysis of molluscum contagiosum virus ORFs by amino acid composition and pI identified a number of ORFs previously denoted as doubtful and highlighted several others that could be similarly classified. The use of amino acid composition and pI appears to be a generally applicable tool to aid identification of viral ORFs that are unlikely to be functional genes.
C Upton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virus genes     Volume:  20     ISSN:  0920-8569     ISO Abbreviation:  Virus Genes     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-07     Completed Date:  2000-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803967     Medline TA:  Virus Genes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Department Biochemistry and Microbiology, University Victoria, BC, Canada.
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MeSH Terms
Amino Acids / analysis
Expressed Sequence Tags
Genome, Viral*
Isoelectric Point
Molluscum contagiosum virus / genetics
Open Reading Frames*
Poxviridae / genetics*
Sequence Alignment
Sequence Analysis, DNA
Vaccinia virus / genetics
Reg. No./Substance:
0/Amino Acids; 0/Codon; 0/Proteome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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