| Screening of plants used in Danish folk medicine to treat depression and anxiety for affinity to the serotonin transporter and inhibition of MAO-A. | |
MedLine Citation:
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PMID: 23266274 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ETHNOPHARMACOLOGICAL RELEVANCE: A number of plant species are used in Danish folk medicine for treatment of depression and anxiety. MATERIALS AND METHODS: Aqueous and ethanolic extracts of 17 plant species were tested for affinity to the serotonin transporter and for inhibition of MAO-A - both targets for antidepressive treatment. RESULTS: An ethanolic extract of aerial parts of Borago officinalis had affinity to the serotonin transporter. Eleven extracts, from 9 plants, had IC(50) values below 25μg/ml extract in the MAO-A assay. The most active extracts in the MAO-A assay were the ethanol extract of seeds of Trigonella foenum-graecum (IC(50) 4μg/ml); ethanol extract of leaves of Apium graveolens (IC(50) 5μg/ml) and the water extract of aerial parts of Calluna vulgaris (IC(50) 8μg/ml). CONCLUSIONS: Besides Borago officinalis, which toxicity profile excludes it from further development as an herbal drug, none of the plants had potential as serotonin reuptake inhibitors. Several plants had MAO-A inhibitory activity. |
Authors:
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Anna K Jäger; Bente Gauguin; Jacob Andersen; Anne Adsersen; Lene Gudiksen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-20 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: - ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen O, Denmark. Electronic address: anna.jager@sund.ku.dk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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