| Screening of non-steroidal anti-inflammatory drugs, barbiturates and methyl xanthines in equine urine by gas chromatography-mass spectrometry. | |
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MedLine Citation:
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PMID: 7879878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A gas chromatographic-mass spectrometric (GC-MS) screening procedure for 23 acidic drugs in equine urine is described. With the GC-MS method fifteen anti-inflammatory drugs, five barbiturates and three methyl xanthines can be detected with good sensitivity and selectivity. The method consists of alkaline hydrolysis, extraction with organic solvent using salting-out, clean-up extraction, methylation and screening with GC-MS in selected-ion monitoring mode. The limit of detection is 10 micrograms 1(-1) or lower, for most drugs. |
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Authors:
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U M Laakkonen; A Leinonen; L Savonen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Analyst Volume: 119 ISSN: 0003-2654 ISO Abbreviation: Analyst Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-03-31 Completed Date: 1995-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372652 Medline TA: Analyst Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2695-6 Citation Subset: IM |
Affiliation:
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United Laboratories Ltd., Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / urine* Barbiturates / urine* Gas Chromatography-Mass Spectrometry / methods Horses / urine* Mass Screening / veterinary Sensitivity and Specificity Xanthines / urine* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Barbiturates; 0/Xanthines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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