Document Detail

Screening for neural tube defects.
MedLine Citation:
PMID:  7516277     Owner:  NLM     Status:  MEDLINE    
The birth prevalence of neural tube defects fell by 95% in England and Wales between 1970 and 1990 largely as a result of antenatal screening, subsequent diagnosis and selective abortion of affected pregnancies. Anencephaly can be diagnosed using ultrasound, whereas both amniotic fluid biochemistry and ultrasound are required for the diagnosis of spina bifida. Both methods have a false-positive rate of about two per 1000 when carried out in high-risk pregnancies. The diagnostic results are likely to be better if the two methods are used in parallel. Maternal serum alpha-fetoprotein screening at 16-18 weeks gestation can detect about 75% of pregnancies affected by spina bifida. Routine ultrasound anomaly screening, usually performed at 18-20 weeks gestation, can detect a similar proportion. New developments indicate that earlier, more accurate detection may be possible but more research will be needed before this can be established.
H S Cuckle
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  181     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1994  
Date Detail:
Created Date:  1994-07-21     Completed Date:  1994-07-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  253-66; discussion 266-9     Citation Subset:  IM    
Department of Clinical Medicine, University of Leeds, UK.
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MeSH Terms
Biochemistry / methods
Mass Screening* / methods
Neural Tube Defects / diagnosis,  prevention & control*,  ultrasonography
Neurology / trends
alpha-Fetoproteins / analysis
Reg. No./Substance:

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