| Screening of nerve agent degradation products by MALDI-TOFMS. | |
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MedLine Citation:
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PMID: 16808484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel method for the rapid screening of degradation products derived from nerve agents by matrix-assisted laser desorption ionization time-of-flight mass spectrometry is described. Five standard products were selected as model compounds, including isopropyl methylphosphonic acid (IMPA), pinacolyl methylphosphonic acid (PMPA), ethyl methylphosphonic acid (EMPA), isobutyl methylphosphonic acid (i-BuMPA), and cyclohexyl methylphosphonic acid (CHMPA), which are degradation products of Sarin (GB), Soman (GD), VX, Russian VX (RVX), and GF, respectively. For comparison, CHCA (alpha-cyano-4-hydroxycinnamic acid) and DCCA (7-(diethylamino)coumarin-3-carboxylic acid) were used as the MALDI-matrix when the third harmonic generation (355 nm) of a Nd:YAG laser and a hydrogen Raman laser (multifrequency laser) were used, respectively. The method permitted the five nerve agent degradation products to be screened rapidly and successfully, suggesting that it has the potential for use as a routine monitoring tool. |
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Authors:
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You-Ren Shu; An-Kai Su; Ju-Tsung Liu; Cheng-Huang Lin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Analytical chemistry Volume: 78 ISSN: 0003-2700 ISO Abbreviation: Anal. Chem. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-30 Completed Date: 2007-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370536 Medline TA: Anal Chem Country: United States |
Other Details:
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Languages: eng Pagination: 4697-701 Citation Subset: IM |
Affiliation:
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Department of Chemistry, National Taiwan Normal University, 88 Section 4, Tingchow Road, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Central Nervous System
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drug effects* Chemical Warfare Agents / analysis*, toxicity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods* |
| Chemical | |
Reg. No./Substance:
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0/Chemical Warfare Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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