| Screening of microalgae for species excreting norharmane, a manifold biologically active indole alkaloid. | |
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MedLine Citation:
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PMID: 16872816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A screening of microalgae strains is described, with the objective to discover more species besides the known cyanobacterium Nodularia harveyana which excrete the manifold biologically active and co-mutagenic indole alkaloid norharmane (9H-pyrido(3,4-b)indole) into their environment. Seven more cyanobacterial species, Anabaena cylindrica, Anabaena inaequalis, Anabaenopsis siamensis, Chroococcus minutus, Nostoc carneum, Nostoc commune and Phormidium foveolarum, were newly discovered. The norharmane concentrations detected for cyanobacterial culture media varied in a species-dependent manner from less than 1 up to 525 microg l(-1). The risk for humans and livestock, resulting from the natural appearance of norharmane as an extracellular metabolite of various cyanobacteria, is discussed. |
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Authors:
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Rainer-B Volk |
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Publication Detail:
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Type: Journal Article Date: 2006-07-26 |
Journal Detail:
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Title: Microbiological research Volume: 163 ISSN: 0944-5013 ISO Abbreviation: Microbiol. Res. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-14 Completed Date: 2008-07-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9437794 Medline TA: Microbiol Res Country: Germany |
Other Details:
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Languages: eng Pagination: 307-13 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Biology, University of Kiel, Pharmaceutical Institute, Kiel, Germany. volk@pharmazie.uni-kiel.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Thin Layer Cyanobacteria / metabolism* Harmine / analogs & derivatives*, chemistry, metabolism, toxicity Humans Indole Alkaloids / metabolism*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Indole Alkaloids; 244-63-3/norharman; 442-51-3/Harmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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