Document Detail

Screening of microalgae for species excreting norharmane, a manifold biologically active indole alkaloid.
MedLine Citation:
PMID:  16872816     Owner:  NLM     Status:  MEDLINE    
A screening of microalgae strains is described, with the objective to discover more species besides the known cyanobacterium Nodularia harveyana which excrete the manifold biologically active and co-mutagenic indole alkaloid norharmane (9H-pyrido(3,4-b)indole) into their environment. Seven more cyanobacterial species, Anabaena cylindrica, Anabaena inaequalis, Anabaenopsis siamensis, Chroococcus minutus, Nostoc carneum, Nostoc commune and Phormidium foveolarum, were newly discovered. The norharmane concentrations detected for cyanobacterial culture media varied in a species-dependent manner from less than 1 up to 525 microg l(-1). The risk for humans and livestock, resulting from the natural appearance of norharmane as an extracellular metabolite of various cyanobacteria, is discussed.
Rainer-B Volk
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Publication Detail:
Type:  Journal Article     Date:  2006-07-26
Journal Detail:
Title:  Microbiological research     Volume:  163     ISSN:  0944-5013     ISO Abbreviation:  Microbiol. Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9437794     Medline TA:  Microbiol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  307-13     Citation Subset:  IM    
Department of Pharmaceutical Biology, University of Kiel, Pharmaceutical Institute, Kiel, Germany.
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MeSH Terms
Chromatography, Thin Layer
Cyanobacteria / metabolism*
Harmine / analogs & derivatives*,  chemistry,  metabolism,  toxicity
Indole Alkaloids / metabolism*,  toxicity
Reg. No./Substance:
0/Indole Alkaloids; 244-63-3/norharman; 442-51-3/Harmine

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