Document Detail

Screening and management of inherited thrombophilias in the setting of adverse pregnancy outcome.
MedLine Citation:
PMID:  15519428     Owner:  NLM     Status:  MEDLINE    
Inherited thrombophilic conditions are associated with adverse pregnancy outcomes, including severe pre-eclampsia, fetal loss, abruptio placentae, and intauterine growth restriction. Although the prevalence of these complications is approximately 8% in the general population, their presence is associated with a significantly increased recurrence risk. Thrombophilic conditions most strongly associated with adverse pregnancy outcome include factor V Leiden, prothrombin gene mutation, and deficiencies of protein S, protein C, and antithrombin. Other thrombophilic conditions, such as protein Z deficiency, also appear to be associated with an increased risk of pregnancy complications. Antenatal administration of heparin to prevent pregnancy complications has shown promise in small studies, but a randomized, placebo-controlled trial is necessary to determine whether heparin administration is beneficial in preventing adverse pregnancy outcome.
Michael J Paidas; De-Hui W Ku; Yale S Arkel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  31     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-02     Completed Date:  2005-01-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  783-805, vii     Citation Subset:  IM    
The Program for Thrombosis and Hemostasis in Women's Health, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, 329 FMB, New Haven, CT 06520-8063, USA.
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MeSH Terms
Abruptio Placentae / etiology
Anticoagulants / administration & dosage*
Eclampsia / etiology
Fetal Death / etiology
Fetal Growth Retardation / etiology
Heparin / administration & dosage
Pre-Eclampsia / etiology
Pregnancy Complications, Hematologic*
Pregnancy Outcome*
Thrombophilia / complications*,  diagnosis*,  drug therapy*
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

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