Document Detail


Screening for latent tuberculosis infection in South Korean healthcare workers using a tuberculin skin test and whole blood interferon-gamma assay.
MedLine Citation:
PMID:  20482459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compared the results of a tuberculin skin test (TST) and a whole-blood interferon-gamma release assay (IGRA) to screen latent tuberculosis (TB) infection (LTBI) according to risk of TB exposure in South Korea. A cross-sectional comparison of 82 healthcare workers (HCWs) was performed from June 2009 to January 2010. Participants were grouped according to their risk for TB exposure: group 1, frequent and direct contact with active TB patients (n = 35); group 2, no known history of direct contact with active TB patients (n = 47). For the TST (10-mm induration cut-off), the positive response rate was 42.9% in group 1 and 34.0% in group 2 (p = 0.42). For the IGRA, the positive response rate was 40% in group 1 and 10.6% in group 2 (p = 0.002). Results obtained from the TST and the IGRA were not in significant agreement. The working duration of HCWs in TB-related departments was the only significant risk factor for LTBI (odds ratio 1.03; p = 0.031). Further, the IGRA can more accurately discriminate LTBI compared to the TST, based on the risk of TB exposure. These results suggest that the IGRA is diagnostically useful for LTBI in South Korean HCWs.
Authors:
Kyung Jong Lee; Young Ae Kang; Young Mi Kim; Sang-Nae Cho; Jin Wook Moon; Moo Suk Park; Se Kyu Kim; Joon Chang; Young Sam Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  42     ISSN:  1651-1980     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-25     Completed Date:  2010-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  672-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chi-Square Distribution
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay / methods*
Female
Health Personnel*
Humans
Interferon-gamma / blood*
Latent Tuberculosis / blood,  diagnosis*
Male
Mass Screening / methods
Middle Aged
Predictive Value of Tests
Republic of Korea
Risk Factors
Statistics, Nonparametric
Tuberculin Test / methods*
Chemical
Reg. No./Substance:
82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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