Document Detail


Screening for late neonatal vitamin K deficiency by acarboxyprothrombin in dried blood spots.
MedLine Citation:
PMID:  3592727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acarboxyprothrombin (protein induced by vitamin K absence or antagonist-II (PIVKA-II] concentrations in dried blood spots were determined in 19,029 infants at about 1 month of age as an indicator of vitamin K deficiency. We observed 51 cases with raised blood concentrations of PIVKA-II (greater than 4 AU/ml), nine of whom showed very high concentrations (greater than 20 AU/ml). For infants who did not receive vitamin K prophylaxis at birth, the incidence of the PIVKA-II test yielding positive results was significantly higher in those solely breast fed (0.51%) compared with those fed formula milk (0.18%). Among solely breast fed infants, the incidence of a very high result of the PIVKA-II test was 0.14% in those who had not received vitamin K prophylaxis at birth, 0.04% in those who received 2 mg orally, and 0.03% in those who received 2 mg orally plus a further dose of 2-4 mg orally at 7 days. Thus vitamin K prophylaxis at birth did not completely prevent vitamin K deficiency at 1 month. We administered vitamin K therapeutically to all infants whose PIVKA-II test yielded a positive result at 1 month. Only one infant with a positive result developed late neonatal intracranial haemorrhage.
Authors:
K Motohara; F Endo; I Matsuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  62     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-09     Completed Date:  1987-07-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  370-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers*
Female
Humans
Infant
Infant, Newborn
Male
Protein Precursors / analysis,  diagnostic use*
Prothrombin / analysis,  diagnostic use*
Vitamin K / therapeutic use
Vitamin K Deficiency / diagnosis*,  metabolism,  prevention & control
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 12001-79-5/Vitamin K; 53230-14-1/acarboxyprothrombin; 9001-26-7/Prothrombin
Comments/Corrections

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