| Screening for late neonatal vitamin K deficiency by acarboxyprothrombin in dried blood spots. | |
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MedLine Citation:
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PMID: 3592727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acarboxyprothrombin (protein induced by vitamin K absence or antagonist-II (PIVKA-II] concentrations in dried blood spots were determined in 19,029 infants at about 1 month of age as an indicator of vitamin K deficiency. We observed 51 cases with raised blood concentrations of PIVKA-II (greater than 4 AU/ml), nine of whom showed very high concentrations (greater than 20 AU/ml). For infants who did not receive vitamin K prophylaxis at birth, the incidence of the PIVKA-II test yielding positive results was significantly higher in those solely breast fed (0.51%) compared with those fed formula milk (0.18%). Among solely breast fed infants, the incidence of a very high result of the PIVKA-II test was 0.14% in those who had not received vitamin K prophylaxis at birth, 0.04% in those who received 2 mg orally, and 0.03% in those who received 2 mg orally plus a further dose of 2-4 mg orally at 7 days. Thus vitamin K prophylaxis at birth did not completely prevent vitamin K deficiency at 1 month. We administered vitamin K therapeutically to all infants whose PIVKA-II test yielded a positive result at 1 month. Only one infant with a positive result developed late neonatal intracranial haemorrhage. |
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Authors:
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K Motohara; F Endo; I Matsuda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of disease in childhood Volume: 62 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-07-09 Completed Date: 1987-07-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 370-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers* Female Humans Infant Infant, Newborn Male Protein Precursors / analysis, diagnostic use* Prothrombin / analysis, diagnostic use* Vitamin K / therapeutic use Vitamin K Deficiency / diagnosis*, metabolism, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Protein Precursors; 12001-79-5/Vitamin K; 53230-14-1/acarboxyprothrombin; 9001-26-7/Prothrombin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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