Document Detail

Screening for intracranial aneurysms in patients with bicuspid aortic valve.
MedLine Citation:
PMID:  20439844     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Bicuspid aortic valve (BAV) is a common congenital heart defect affecting half to 2% of the population. A generalized connective tissue disorder also involving the intracranial arteries has been suspected in this patient population. We therefore screened a group of patients with BAV for the presence of intracranial aneurysms. METHODS: Magnetic resonance angiography or CT angiography of the brain was used in 61 patients with BAV (age, 29-70 years [mean 48 years]) and in 291 controls (28-78 years [mean 56 years]). RESULTS: Intracranial aneurysms were detected in 6 of 61 patients with BAV (9.8%; 95% confidence interval [CI] 2.4%-17.3%). This was significantly higher than in the control population (3/291 [1.1%; 95% CI 0%-2.2%]) (p = 0.0012). Female sex (p = 0.02) and advanced age (p = 0.003), risk factors for intracranial aneurysm development, were more common in the control population than among the patients with a BAV. No significant differences were detected in age, sex, smoking, arterial hypertension, alcohol use, aortic diameter, or frequency of aortic coarctation between BAV patients with and without intracranial aneurysms. CONCLUSION: In this case-control study, the frequency of intracranial aneurysms among our bicuspid aortic valve patient population was significantly higher than in the control population.
Wouter I Schievink; Sharo S Raissi; M Marcel Maya; Arlys Velebir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  74     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1430-3     Citation Subset:  AIM; IM    
Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 Third Street, Suite 800E, Los Angeles, CA 90048, USA.
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MeSH Terms
Aortic Valve / abnormalities*
Case-Control Studies
Cerebrovascular Circulation
Heart Defects, Congenital / complications*
Intracranial Aneurysm* / diagnosis,  etiology
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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