Document Detail

Screening for in vitro anti-tumor-promoting activities of edible plants from Indonesia.
MedLine Citation:
PMID:  9824374     Owner:  NLM     Status:  MEDLINE    
A total of 135 methanol extracts from 48 plant families (107 species) of edible Indonesian plants were screened for their in vitro anti-tumor-promoting activities using the tumor promoter 12-O-hexadecanoylphorbol-13-acetate (HPA)induced Epstein-Barr virus (EBV) activation test in Raji cells. Examined at a concentration of 200 mg/ml, 71% of the extracts inhibited EBV activation by 30% or more. The rate is comparable to the rate observed in our previous tests of edible Thai (60%) plants and much higher than the rate (26%) observed with Japanese plants. In particular, the plant families Zingiberaceae (13/13 active) and Umbelliferae (7/8 active) are suggested to be desirable sources of effective cancer-preventive agents because of the strikingly high frequency of inhibitory activity. Thus, a high potential of edible Southeast Asian plants for cancer chemoprevention is indicated.
A Murakami; H Morita; R Safitri; A Ramlan; K Koshimizu; H Ohigashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer detection and prevention     Volume:  22     ISSN:  0361-090X     ISO Abbreviation:  Cancer Detect. Prev.     Publication Date:  1998  
Date Detail:
Created Date:  1999-06-17     Completed Date:  1999-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704778     Medline TA:  Cancer Detect Prev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  516-25     Citation Subset:  IM    
Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki University, Iwade-Uchita, Wakayama, Japan.
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MeSH Terms
Antineoplastic Agents / isolation & purification*
Apiaceae / chemistry
Brassicaceae / chemistry
Drug Screening Assays, Antitumor / methods
Euphorbiaceae / chemistry
Fruit / chemistry
Lymphoma, B-Cell
Plants, Edible / chemistry*
Vegetables / chemistry
Zingiberales / chemistry
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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