| Screening for impulse control symptoms in patients with de novo Parkinson disease: a case-control study. | |
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MedLine Citation:
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PMID: 23296128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the frequency and correlates of impulse control and related behavior symptoms in patients with de novo, untreated Parkinson disease (PD) and healthy controls (HCs). METHODS: The Parkinson's Progression Markers Initiative is an international, multisite, case-control clinical study conducted at 21 academic movement disorders centers. Participants were recently diagnosed, untreated PD patients (n = 168) and HCs (n = 143). The outcome measures were presence of current impulse control and related behavior symptoms based on recommended cutoff points for the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP)-Short Form. RESULTS: There were 311 participants with complete QUIP data. Frequencies of impulse control and related behavior symptoms for patients with PD vs HCs were as follows: gambling (1.2% vs. 0.7%), buying (3.0% vs. 2.1%), sexual behavior (4.2% vs. 3.5%), eating (7.1% vs. 10.5%), punding (4.8% vs. 2.1%), hobbyism (5.4% vs. 11.9%), walkabout (0.6% vs. 0.7%), and any impulse control or related behavior (18.5% vs. 20.3%). In multivariable models, a diagnosis of PD was not associated with symptoms of any impulse control or related behavior (p ≥ 0.10 in all cases). CONCLUSIONS: PD itself does not seem to confer an increased risk for development of impulse control or related behavior symptoms, which further reinforces the reported association between PD medications and impulse control disorders in PD. Given that approximately 20% of patients with newly diagnosed PD report some impulse control or related behavior symptoms, long-term follow-up is needed to determine whether such patients are at increased risk for impulse control disorder development once PD medications are initiated. |
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Authors:
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Daniel Weintraub; Kimberly Papay; Andrew Siderowf; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 80 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-08 Completed Date: 2013-03-01 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 176-80 Citation Subset: AIM; IM |
Affiliation:
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University of Pennsylvania School of Medicine, Philadelphia, PA, USA. daniel.weintraub@uphs.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers Disease Progression Female Gambling / psychology Humans Impulse Control Disorders / diagnosis*, epidemiology, etiology* Male Middle Aged Neuropsychological Tests Parkinson Disease / complications*, diagnosis*, epidemiology Psychiatric Status Rating Scales Questionnaires Research Design Risk |
| Grant Support | |
ID/Acronym/Agency:
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P50 NS053488/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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