Document Detail

Screening for impulse control symptoms in patients with de novo Parkinson disease: a case-control study.
MedLine Citation:
PMID:  23296128     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the frequency and correlates of impulse control and related behavior symptoms in patients with de novo, untreated Parkinson disease (PD) and healthy controls (HCs).
METHODS: The Parkinson's Progression Markers Initiative is an international, multisite, case-control clinical study conducted at 21 academic movement disorders centers. Participants were recently diagnosed, untreated PD patients (n = 168) and HCs (n = 143). The outcome measures were presence of current impulse control and related behavior symptoms based on recommended cutoff points for the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP)-Short Form.
RESULTS: There were 311 participants with complete QUIP data. Frequencies of impulse control and related behavior symptoms for patients with PD vs HCs were as follows: gambling (1.2% vs. 0.7%), buying (3.0% vs. 2.1%), sexual behavior (4.2% vs. 3.5%), eating (7.1% vs. 10.5%), punding (4.8% vs. 2.1%), hobbyism (5.4% vs. 11.9%), walkabout (0.6% vs. 0.7%), and any impulse control or related behavior (18.5% vs. 20.3%). In multivariable models, a diagnosis of PD was not associated with symptoms of any impulse control or related behavior (p ≥ 0.10 in all cases).
CONCLUSIONS: PD itself does not seem to confer an increased risk for development of impulse control or related behavior symptoms, which further reinforces the reported association between PD medications and impulse control disorders in PD. Given that approximately 20% of patients with newly diagnosed PD report some impulse control or related behavior symptoms, long-term follow-up is needed to determine whether such patients are at increased risk for impulse control disorder development once PD medications are initiated.
Daniel Weintraub; Kimberly Papay; Andrew Siderowf;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  80     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-03-01     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  176-80     Citation Subset:  AIM; IM    
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MeSH Terms
Biological Markers
Disease Progression
Gambling / psychology
Impulse Control Disorders / diagnosis*,  epidemiology,  etiology*
Middle Aged
Neuropsychological Tests
Parkinson Disease / complications*,  diagnosis*,  epidemiology
Psychiatric Status Rating Scales
Research Design
Grant Support
Reg. No./Substance:
0/Biological Markers
Comment In:
Neurology. 2013 Aug 13;81(7):694-5   [PMID:  23940022 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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