Document Detail


Screening for hb constant spring in the guangdong province, South china, using the sebia capillary electrophoresis system.
MedLine Citation:
PMID:  21250886     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hb Constant Spring [Hb CS; α142, Term→Gln (TAA>CAA in α2)] is a nondeletional α-thalassemia (α-thal) defect difficult to detect on conventional electrophoresis because of its small amount in heterozygotes. We have found that individuals with an Hb CS trait could efficiently be detected using the Sebia capillarys 2 system. In the present study, we have confirmed this method in a cohort of 23,842 individuals from Guangdong Province (South China). Hb CS was detected in 71 (0.3%) of the cases. The levels of Hb CS in heterozygotes ranged from 0.1-1.0% with an average of 0.6%. We propose the reported 0.3% as a realistic figure for the prevalence of Hb CS in South China.
Authors:
Can Liao; Jian-Ying Zhou; Xing-Mei Xie; Dong-Zhi Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hemoglobin     Volume:  35     ISSN:  1532-432X     ISO Abbreviation:  Hemoglobin     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705865     Medline TA:  Hemoglobin     Country:  England    
Other Details:
Languages:  eng     Pagination:  87-90     Citation Subset:  IM    
Affiliation:
Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China.
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