Document Detail

Screening for gestational diabetes mellitus in the subsequent pregnancy: is it worthwhile?
MedLine Citation:
PMID:  12388977     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine, among women without evidence of gestational diabetes mellitus during their first pregnancy, the likelihood of, and associated risk factors for, the development of gestational diabetes mellitus in the subsequent pregnancy. STUDY DESIGN: This was a retrospective cohort study, with a time frame of 1991 to 1999. RESULTS: Of 3710 women without gestational diabetes mellitus in the first pregnancy, 1% (37 women) were subsequently diagnosed with gestational diabetes mellitus in the second pregnancy. These 37 women, when compared (by means) to women without gestational diabetes mellitus in their second pregnancy, were more likely to be older (age 21 years vs 19 years) and obese (first visit body mass index, 28 kg/m(2) vs 25 kg/m(2)) and to have an interpregnancy weight gain of >5 kg (93% vs 49%) and a longer mean interpregnancy interval (33 months vs 24 months). Regression analysis revealed that, during the first pregnancy, a first visit body mass index of >29 kg/m(2) (odds ratio, 2.2; 95% CI, 1.1-4.5) and a serum glucose screen of >101 mg/dL (odds ratio, 8.3; 95% CI, 2.5-27.9) were associated significantly with the development of gestational diabetes mellitus in the second pregnancy, as was an interpregnancy weight gain of >5 kg (odds ratio, 10.8; 95% CI, 2.5-46.3). All women who subsequently had gestational diabetes mellitus had at least one of these risk factors. CONCLUSION: Among women without gestational diabetes mellitus in the first pregnancy, the risk of gestational diabetes mellitus in a second pregnancy is low. Therefore, screening all such women in the second pregnancy may not be justified.
George C Lu; Angela Luchesse; Victoria Chapman; Suzanne Cliver; Dwight J Rouse
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  187     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-21     Completed Date:  2002-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  918-21     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Center for Research in Women's Health, University of Alabama at Birmingham, Birmingham, AL, USA.
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MeSH Terms
Cohort Studies
Diabetes, Gestational / diagnosis*,  etiology*
Mass Screening*
Odds Ratio
Retrospective Studies
Risk Factors
Unnecessary Procedures
Grant Support
1K24 HD 01375-01/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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