Document Detail

Screening of forme fruste keratoconus with the ocular response analyzer.
MedLine Citation:
PMID:  19907025     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the performance of the Ocular Response Analyzer (ORA) in the screening of forme fruste keratoconus (FFKc). METHODS: A retrospective comparative study was conducted involving 180 eyes. ORA preoperative data were analyzed for 125 normal control eyes (64 patients) undergoing laser in situ keratomileusis (LASIK) without corneal ectasia after 24 months of follow-up and 55 case eyes with unilateral keratoconus from a database (BCVA of 1.0, KISA index <60%). All eyes were matched in four groups of central corneal thickness (CCT): group 1, <500 microm; group 2, 500 to 539 microm; group 3, 540 to 579 microm; and group 4 >580 microm. Corneal hysteresis (CH), the corneal resistance factor (CRF), the air pressure curve, and the infrared signal were compared between FFKc and normal eyes in each group. RESULTS: The mean CH was 9.1 +/- 1.8 mm Hg for FFKc and 10.3 +/- 1.9 mm Hg for control eyes (P < 0.001), and the mean CRF was 9.2 +/- 1.8 and 11.1 +/- 2 mm Hg (P < 0.001), respectively. Sensitivity in each group was as follows: group 1, CH < 9.5 mm Hg (91%) and CRF < 9.5 mm Hg (81%); group 2, CH < 10.5 mm Hg (91%) and CRF < 10 mm Hg (87%); group 3, CH < 11.5 mm Hg (79%) and CRF < 11 mm Hg (74%); group 4 had two cases of FFKc, and the difference was not significant. Air pressure levels at inward and outward applanation and the maximum air pressure level were significantly lower and shorter in time in FFKc (P < 0.001), whereas the shape of the infrared signal was more variable. CONCLUSIONS: The ORA provides additional information in the screening of FFKc, with an accurate analysis of the corneal biomechanical properties according to CCT, air pressure, and infrared curves.
Cedric Schweitzer; Cynthia J Roberts; Ashraf M Mahmoud; Joseph Colin; Sylvie Maurice-Tison; Julien Kerautret
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-11-11
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  51     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2403-10     Citation Subset:  IM    
National Reference Center for Keratoconus, Department of Ophthalmology, University Hospital Pellegrin, Bordeaux, France.
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MeSH Terms
Cornea / pathology*
Diagnostic Techniques, Ophthalmological*
Dilatation, Pathologic
Follow-Up Studies
Keratoconus / diagnosis*,  surgery
Keratomileusis, Laser In Situ
ROC Curve
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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