| Screening of exhaled breath by low-resolution multicomponent FT-IR spectrometry in patients attending emergency departments. | |
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MedLine Citation:
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PMID: 15068564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interest in noninvasive methods for disease diagnosis is increasing. In this study, we tested the utility and potential of a portable Fourier transform infrared (FT-IR) multicomponent analyzer in the emergency rooms (ERs) of two Finnish hospitals. Major detected breath volatiles in this population were ethanol, carbon monoxide, methane, and acetone, in addition to carbon dioxide and water. The analysis of breath revealed an ethanol concentration of over 25 ppm (0.1 g/L in blood) in 56 out of 589 patients (9.5%). During nightshifts the proportion was 30% for all and 63% for trauma patients. Five-hundred eighty-four patients had measurable carbon monoxide in their breath. A breath carbon monoxide of over 4 ppm (4.4 micro g/L) differentiated smokers from nonsmokers. Methane over 2 ppm (1.3 micro g/L) was detected in the breath of 32% of the participants. Methane concentration was higher among aged patients. Two-hundred ninety-eight participants had detectable acetone in their breath. Elevated exhaled acetone [10-76 ppm (23-75 micro g/L)] was detected in 10 patients. The FT-IR method proved functional in the ER setting. A major advantage over blood sampling was fast and easy analysis performed by nonlaboratory personnel. |
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Authors:
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Olli Laakso; Matti Haapala; Tapio Kuitunen; Jaakko-Juhani Himberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 28 ISSN: 0146-4760 ISO Abbreviation: J Anal Toxicol Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-04-07 Completed Date: 2004-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 111-7 Citation Subset: IM |
Affiliation:
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Hyvinkää Hospital, Department of Anesthesiology and Intensive Care Medicine, Sairaalankatu 1, 05850 Hyvinkää, Finland. olli.laakso@pp1.inet.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetone
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analysis Adolescent Adult Aged Aged, 80 and over Breath Tests / methods* Carbon Monoxide / analysis Emergency Medical Services / methods* Ethanol / analysis Female Humans Male Middle Aged Spectroscopy, Fourier Transform Infrared / methods* |
| Chemical | |
Reg. No./Substance:
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630-08-0/Carbon Monoxide; 64-17-5/Ethanol; 67-64-1/Acetone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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