Document Detail

Screening of exhaled breath by low-resolution multicomponent FT-IR spectrometry in patients attending emergency departments.
MedLine Citation:
PMID:  15068564     Owner:  NLM     Status:  MEDLINE    
Interest in noninvasive methods for disease diagnosis is increasing. In this study, we tested the utility and potential of a portable Fourier transform infrared (FT-IR) multicomponent analyzer in the emergency rooms (ERs) of two Finnish hospitals. Major detected breath volatiles in this population were ethanol, carbon monoxide, methane, and acetone, in addition to carbon dioxide and water. The analysis of breath revealed an ethanol concentration of over 25 ppm (0.1 g/L in blood) in 56 out of 589 patients (9.5%). During nightshifts the proportion was 30% for all and 63% for trauma patients. Five-hundred eighty-four patients had measurable carbon monoxide in their breath. A breath carbon monoxide of over 4 ppm (4.4 micro g/L) differentiated smokers from nonsmokers. Methane over 2 ppm (1.3 micro g/L) was detected in the breath of 32% of the participants. Methane concentration was higher among aged patients. Two-hundred ninety-eight participants had detectable acetone in their breath. Elevated exhaled acetone [10-76 ppm (23-75 micro g/L)] was detected in 10 patients. The FT-IR method proved functional in the ER setting. A major advantage over blood sampling was fast and easy analysis performed by nonlaboratory personnel.
Olli Laakso; Matti Haapala; Tapio Kuitunen; Jaakko-Juhani Himberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  28     ISSN:  0146-4760     ISO Abbreviation:  J Anal Toxicol     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-07     Completed Date:  2004-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  IM    
Hyvinkää Hospital, Department of Anesthesiology and Intensive Care Medicine, Sairaalankatu 1, 05850 Hyvinkää, Finland.
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MeSH Terms
Acetone / analysis
Aged, 80 and over
Breath Tests / methods*
Carbon Monoxide / analysis
Emergency Medical Services / methods*
Ethanol / analysis
Middle Aged
Spectroscopy, Fourier Transform Infrared / methods*
Reg. No./Substance:
630-08-0/Carbon Monoxide; 64-17-5/Ethanol; 67-64-1/Acetone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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