Document Detail

Screening for ectopic pregnancy in symptom-free women at increased risk.
MedLine Citation:
PMID:  9166305     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the ectopic pregnancy rate among symptom-free women at increased risk undergoing a screening program involving transvaginal sonography and serum hCG testing. METHODS: Consecutive symptom-free women at increased risk for ectopic pregnancy were studied prospectively by transvaginal sonography and serum hCG measurement to detect ectopic pregnancy before the onset of symptoms. RESULTS: Between September 1993 and May 1996, 143 symptom-free pregnant women with pregnancies of a gestational age of less than 7 weeks were screened. Eight had ectopic pregnancies, 129 had intrauterine pregnancies, and six had trophoblast in regression. Among the eight women with ectopic pregnancies, one was initially diagnosed as having an intrauterine pregnancy. This women returned 1 week later with abdominal pain, and an ectopic pregnancy with intra-abdominal bleeding was found. Ectopic pregnancies were present in 5.6% (95% confidence interval 2.5%, 10.7%) of the women screened. This was significantly lower than reported in a previous study. CONCLUSION: The ectopic pregnancy rate in the population that was offered screening was low. Thus, it is questionable whether the possible benefits (prevention of complications and reassurance of the woman) outweigh possible detriments (false-positive diagnosis, financial costs, and emotional stress that could be induced by screening.
B W Mol; P J Hajenius; W M Ankum; P M Bossuyt; F van der Veen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  89     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  704-7     Citation Subset:  AIM; IM    
Department of Clinical Epidemiology and Biostatistics, University of Amsterdam, The Netherlands.
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MeSH Terms
Chorionic Gonadotropin / blood*
Mass Screening* / methods
Pregnancy, Ectopic / blood,  prevention & control*,  ultrasonography
Pregnancy, High-Risk*
Prospective Studies
Risk Factors
Sensitivity and Specificity
Ultrasonography, Prenatal* / standards
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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