| Screening and early postnatal management strategies to prevent hazardous hyperbilirubinemia in newborns of 35 or more weeks of gestation. | |
| | |
MedLine Citation:
|
PMID: 20034861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although kernicterus is a rare condition, it is still being reported in North America and Western Europe in addition to less developed parts of the world. The majority of affected infants are term and late-preterm newborns who have been discharged from the nursery as 'healthy newborns' yet have subsequently developed extreme hyperbilirubinemia and the classic neurodevelopmental findings associated with kernicterus. Published guidelines provide the basic tools for preventing hazardous hyperbilirubinemia and the two most important of these are a systematic assessment, prior to discharge, of each infant, for the risk of severe hyperbilirubinemia, and appropriate follow-up based on the time of discharge and the risk assessment. The most recent recommendations call for a predischarge measurement of the serum or transcutaneous bilirubin in all infants. When combined with the gestational age and other risk factors for hyperbilirubinemia, this provides the best estimate of the risk, or lack of risk, for subsequent hyperbilirubinemia, and determines the timing of follow-up and the need for further evaluation and treatment. The application of these principles to the management of the jaundiced newborn might not eliminate every case of kernicterus, but should contribute to a reduction in its occurrence. |
| | |
Authors:
|
M Jeffrey Maisels |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-01-19 |
Journal Detail:
|
Title: Seminars in fetal & neonatal medicine Volume: 15 ISSN: 1878-0946 ISO Abbreviation: Semin Fetal Neonatal Med Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-04-26 Completed Date: 2010-09-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101240003 Medline TA: Semin Fetal Neonatal Med Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 129-35 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Pediatrics, Oakland University William Beaumont School of Medicine, Division of Neonatology, Beaumont Children's Hospital, Royal Oak, Michigan 48073, USA. jmaisels@beaumont.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bilirubin
/
blood* Guidelines as Topic Humans Hyperbilirubinemia, Neonatal / blood, diagnosis, pathology, prevention & control* Infant, Newborn / blood* Kernicterus / blood, diagnosis, pathology, prevention & control Neonatal Screening / methods Nomograms Risk Assessment |
| Chemical | |
Reg. No./Substance:
|
635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ursodeoxycholic acid treatment in patients with cystic fibrosis at risk for liver disease.
Next Document: Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.