Document Detail


Screening for early lung cancer. Results of the Memorial Sloan-Kettering study in New York.
MedLine Citation:
PMID:  6734291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Memorial Sloan-Kettering lung cancer screening program was begun in 1974 to evaluate sputum cytology as a supplement to the annual chest x-ray examination for early detection and diagnosis. The 10,040 adult, male cigarette smokers who enrolled were randomly assigned to receive annual chest x-ray examinations only or a dual screen with annual chest x-ray examination and four monthly sputum cytology evaluation. Over 40 percent of the 288 who developed lung cancer were diagnosed in stage I, and their survival was 76 percent at five years; overall survival was 35 percent. Nearly one third of the lung cancers detected on first examination on the dual screen, and 14 percent of those on subsequent examinations were found by cytologic examination. The same number of cancers developed in the x-ray screen only group, and were diagnosed at a later date. Despite the delay, survival and mortality were the same, suggesting that the squamous carcinomas detected by cytologic examination alone are very slow growing and tend to remain localized until detectable by x-ray examination.
Authors:
M R Melamed; B J Flehinger; M B Zaman; R T Heelan; W A Perchick; N Martini
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Chest     Volume:  86     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-03     Completed Date:  1984-08-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-53     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Carcinoma / diagnosis*,  mortality,  radiography
Humans
Lung Neoplasms / diagnosis*,  mortality,  radiography
Male
Middle Aged
Sputum / cytology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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