Document Detail


Screening for congenital hypothyroidism. II. Clinical findings in infants with positive screening tests.
MedLine Citation:
PMID:  7234398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a pilot screening programme for congenital hypothyroidism, PKU filter paper blood samples from 20 000 infants born in Stockholm were analysed for TSH and T4 to identify optimal conditions for routine nationwide screening. Among 160 infants with positive screening tests, 7 infants (group I) had true-positive results, 6 had primary and one secondary hypothyroidism. The 153 infants with false-positive tests were divided into group II:74 infants with an isolated increased TSH level; group III: 71 infants with an isolated decreased T4 concentration; and group IV: 8 infants with increased TSH and decreased T4 levels. In group I the clinical signs and symptoms of hypothyroidism varied when the diagnosis was made at 3 weeks of age. The median hypothyroid index score was 8 (range 0--18). In groups II-IV most infants showed very few signs of hypothyroidism. The median hypothyroid index scores were 1, 1, and 0, respectively. Clinical findings were of little value in the individual case for distinguishing true from false positive screening tests. We suggest that nation-wide screening should be based on TSH analyses of PKU blood samples, with a cut-off level corresponding to 50 mU/l of plasma. Recall frequency will be less than 0.1%.
Authors:
A Larsson; J G Ljunggren; K Ekman; A Nilsson; P Olin; G Bodegård
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  70     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-07-09     Completed Date:  1981-07-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Congenital Hypothyroidism*
Follow-Up Studies
Humans
Hypothyroidism / diagnosis
Infant, Newborn
Mass Screening
Pilot Projects
Sweden
Thyrotropin / blood
Thyroxine / blood
Chemical
Reg. No./Substance:
7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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