Document Detail


Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line.
MedLine Citation:
PMID:  22310494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The zebrafish lateral line is an efficient model system for the evaluation of chemicals that protect and damage hair cells. Located on the surface of the body, lateral line hair cells are accessible for manipulation and visualization. The zebrafish lateral line system allows rapid screens of large chemical libraries, as well as subsequent thorough evaluation of interesting compounds. In this review, we focus on the results of our previous screens and the evolving methodology of our screens for chemicals that protect hair cells, and chemicals that damage hair cells using the zebrafish lateral line.
Authors:
Henry Ou; Julian A Simon; Edwin W Rubel; David W Raible
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-01-31
Journal Detail:
Title:  Hearing research     Volume:  288     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-08     Completed Date:  2012-10-10     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  58-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Death / drug effects
Cell Survival / drug effects
Cytoprotection
Hair Cells, Auditory, Inner / drug effects*,  pathology
Lateral Line System / drug effects*,  pathology
Mass Screening / methods*
Neuroprotective Agents / pharmacology*
Toxicity Tests / methods*
Zebrafish*
Grant Support
ID/Acronym/Agency:
K08 DC009631/DC/NIDCD NIH HHS; K08 DC009631-01A1/DC/NIDCD NIH HHS; P30 DC004661/DC/NIDCD NIH HHS; P30 DC004661-01/DC/NIDCD NIH HHS; R01 DC005987/DC/NIDCD NIH HHS; R01 DC005987-05/DC/NIDCD NIH HHS; R01 DC009807/DC/NIDCD NIH HHS; R01 DC009807-01A1/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Neuroprotective Agents
Comments/Corrections

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