Document Detail


Screening by anti-endomysium antibody for celiac disease in diabetic children and adolescents in Austria.
MedLine Citation:
PMID:  10776949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Unrecognized celiac disease (CD) may be found in a substantial proportion of patients with type I diabetes mellitus. METHODS: A cohort of 403 Austrian children and adolescents with type I diabetes mellitus (210 males and 193 females; age range, 1-22 years) was screened for celiac disease using the IgA anti-endomysium antibody test (EMA) and the immunoglobulin (Ig)G anti-gliadin (AGA-IgG) and IgA anti-gliadin (AGA-IgA) antibody test. RESULTS: Twelve patients' sera (2.98%) yielded positive EMA results and two patients' sera (0.49%) with IgA deficiency had high AGA-IgG values. All but one of these patients underwent intestinal biopsy. Six (1.49%) had clear histologic evidence of CD (flat mucosa), whereas three (0.74%) showed minor histologic changes (increase in intraepithelial lymphocytes) and four (0.99%), including the EMA-negative patients with IgA deficiency, had a normal mucosa. When the cases with silent and potential CD were combined, the overall prevalence in the current cohort was 2.98%. There was no difference in the hemoglobin (Hb)A1c level between antibody-positive and -negative patients, and subsequent gluten-free diet did not change this metabolic parameter. CONCLUSION: The prevalence of clinically unrecognized CD, found by EMA screening, is much higher in Austrian children with diabetes than in a comparable population without diabetes. The prevalence of CD in diabetic children in Austria is distinctly lower, however, than in several other countries.
Authors:
E Schober; B Bittmann; G Granditsch; W D Huber; A Hüppe; A Jäger; G Oberhuber; B Rami; G Reichel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  30     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-07-27     Completed Date:  2000-07-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Austria / epidemiology
Autoantibodies / blood*
Biological Markers / blood
Celiac Disease / complications,  diagnosis*,  epidemiology*,  pathology
Child
Child, Preschool
Diabetes Mellitus, Type 1 / complications*
Female
Gliadin / immunology
Humans
Immunoglobulin G / immunology
Infant
Male
Mass Screening / methods
Muscle Fibers, Skeletal / immunology*
Prevalence
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/Immunoglobulin G; 9007-90-3/Gliadin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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