Document Detail


Screening for biochemical abnormalities in urolithiasis patients.
MedLine Citation:
PMID:  15455621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The significance of biochemical screening in stone formers has been a debated topic. This study was conducted to investigate the frequency of biochemical abnormalities in our urolithiasis patients and to compare the abnormality between the first time and recurrent stone formers so that this information would help in assessing the value of biochemical screening in our practice. METHODS: Over a twenty-one month period, new and recurrent stone disease patients had one random blood specimen and two random 24-hour urine collections analysed for biochemical abnormalities. Serum was checked for calcium, urate, phosphate and creatinine. The urines were measured for volumes, calcium, oxalate, urate, citrate, cystine and pH. RESULTS: Out of total of 113 patients, 83 (73%) had some urinary or blood abnormality. Highest number of abnormalities were in urine. Low volume 33 (39.76%), hypercalciuria 33 (39.76%) and hyperoxaluria 20 (24.1%) were the main urinary abnormalities. Elevated serum creatinine in 10 (12.05%) was commonest blood abnormality. Females had significantly higher frequencies of low urinary volume (48% vs 21%, p=0.001), hyperoxaluria (38% vs 11%, p=0.002) and hypocitraturia (37% vs 0%, p<0.001). There was no significant difference of abnormality rate between first time and recurrent stone formers. CONCLUSION: A high frequency of urinary biochemical abnormality and equal abnormality frequencies among first time and recurrent stone formers highlights the significance of biochemical screening even in cases of initial stone presentation. We feel such diagnostic evaluation would help in providing precise treatment and efficient prophylaxis.
Authors:
Nasir Orakzai; Damian C Hanbury; Kenneth Farrington
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Ayub Medical College, Abbottabad : JAMC     Volume:  16     ISSN:  1025-9589     ISO Abbreviation:  J Ayub Med Coll Abbottabad     Publication Date:    2004 Apr-Jun
Date Detail:
Created Date:  2004-09-30     Completed Date:  2004-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910750     Medline TA:  J Ayub Med Coll Abbottabad     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  60-3     Citation Subset:  IM    
Affiliation:
Department of Urology, Lister Hospital, Coreys Mill Lane, Stevenage, UK. pines@brain.net.pk
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Bicarbonates / blood
Calcium / blood,  urine
Citric Acid / urine
Creatinine / blood
Female
Humans
Male
Middle Aged
Oxalates / urine
Phosphates / blood
Recurrence
Uric Acid / blood,  urine
Urinary Calculi / blood*,  urine*
Urine
Chemical
Reg. No./Substance:
0/Bicarbonates; 0/Oxalates; 0/Phosphates; 60-27-5/Creatinine; 69-93-2/Uric Acid; 7440-70-2/Calcium; 77-92-9/Citric Acid

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