Document Detail


Screening for adverse pregnancy outcome at early gestational age.
MedLine Citation:
PMID:  20599860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the past two decades second-trimester maternal serum screening for Down syndrome has been the most common strategy for prenatal diagnosis of chromosomal aneuploidies. More recently, screening for and diagnosis of chromosomal abnormalities have increasingly been performed in the first trimester. With improvements and technological advances in ultrasound, it is now possible to identify many fetal anomalies at 11-13 weeks of gestation. During the same period biochemical markers in maternal serum (PAPP-A and hCGβ) combined with sonographic measurement of nuchal translucency achieve a Down syndrome detection rate of 85% with a 5% false-positive rate. We describe here the potential of first-trimester markers to screen for Down syndrome as well as other adverse outcomes such as fetal loss, pre-eclampsia, intrauterine growth retardation, and preterm delivery. This early consultation may be the opportunity to help counsel patients and to screen for other adverse complications during pregnancy, such as pre-eclampsia, and to manage potential adverse pregnancy outcomes.
Authors:
Sophie Hourrier; Laurent J Salomon; Sophie Dreux; Françoise Muller
Publication Detail:
Type:  Journal Article; Review     Date:  2010-06-27
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  411     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1547-52     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. All rights reserved.
Affiliation:
Gynécologie-Obstétrique, Hôpital Necker Enfants Malades AP-HP, 75015, Paris, France, Université Paris Descartes.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis
Female
Humans
Pregnancy
Pregnancy Complications / diagnosis*
Pregnancy Outcome
Pregnancy Trimester, First
Prenatal Diagnosis / methods*
Chemical
Reg. No./Substance:
0/Biological Markers

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