| Screening and adenocarcinoma of the cervix. | |
| | |
MedLine Citation:
|
PMID: 19449379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Screening has had a major impact on cervical cancer in many countries. Although there can be no doubt about its effectiveness in preventing squamous-cell carcinoma, there is little evidence of any benefit on adenocarcinoma and adenosquamous carcinoma of the cervix, and many authors have concluded that it is ineffective. A population-based case-control design was used in women aged 20-69 in the United Kingdom, with information on screening obtained from routine databases. Among 3,305 cases with known histology, 641 had adenocarcinoma and 133 adenosquamous carcinoma. The risk reduction associated with 3-yearly screening was greater for squamous carcinoma (75%, 95%CI 71-79%) and adenosquamous carcinoma (83%, 95%CI 68-91%) than for adenocarcinoma (43%, 95%CI 24-58%). Among stage 1B+ cases, 83% (335/406) of women with adenocarcinoma had been screened within 10 years of diagnosis. This is very similar to controls (82%, 3,292/3,965), but much higher than in women with squamous carcinoma (57%, 852/1,493). Incidence of adenocarcinoma was low within 2.5 years of a negative smear (OR 2.3, 95%CI 0.15-0.34), but was no different from the background rates 4.5-5.5 years after a negative smear. We conclude that screening has reduced the incidence of adenocarcinoma of the cervix, but the prognostic value of cytology is less (in both magnitude and duration) for adenocarcinoma than for squamous carcinoma. The impact of screening on adenosquamous carcinoma is similar to its impact on squamous carcinoma. |
| | |
Authors:
|
Peter Sasieni; Alejandra Castanon; Jack Cuzick |
Related Documents
:
|
6612569 - Acute carcinoma of the breast. 9227339 - The pathological and biological nature of screen-detected breast carcinomas: a morpholo... 18407739 - Clinical proteomics and breast cancer: strategies for diagnostic and therapeutic biomar... 15473589 - Current dilemmas and future perspectives for breast cancer screening with a focus on op... 18989129 - Screening for breast cancer in england: a review. 11198269 - Breast cancer screening among cambodian american women. 23087329 - Her2 amplification distinguishes a subset of non-muscle-invasive bladder cancers with a... 10349989 - Reasoning with uncertainty in pathology: artificial neural networks and logistic regres... 10394339 - Comparison of the conventional 'box technique' with two different 'conformal' beam arra... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of cancer. Journal international du cancer Volume: 125 ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-07-06 Completed Date: 2009-07-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 525-9 Citation Subset: IM |
Affiliation:
|
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart's & The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
diagnosis,
epidemiology*,
pathology,
prevention & control* Adult Aged Carcinoma, Adenosquamous / diagnosis, epidemiology*, pathology, prevention & control* Carcinoma, Squamous Cell / epidemiology, prevention & control Case-Control Studies Colposcopy Female Great Britain / epidemiology Humans Incidence Logistic Models Mass Screening* / methods Middle Aged Neoplasm Invasiveness Uterine Cervical Neoplasms / diagnosis, epidemiology*, pathology, prevention & control* |
| Grant Support | |
ID/Acronym/Agency:
|
C569/A5030//Cancer Research UK; C8162/A6127//Cancer Research UK |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City.
Next Document: In vivo differentiation of two vessel wall layers in lower extremity peripheral vein bypass grafts: ...