Document Detail

Screening for acute myocarditis--is scintigraphy with (99m)Tc-Anti-Granulocyte BW 250/183 an answer?
MedLine Citation:
PMID:  15968604     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Myocarditis is most often caused by Coxackie B virus, influenza viruses, and echoviruses. It is usually self-restricting and ending in full recovery, but in some patients the infection leads to congestive cardiomyopathy. It is difficult to identify patients with myocarditis using clinical criteria, laboratory tests, ECG and ultrasonography, and currently a myocardial biopsy is required to establish the diagnosis. The risk of complications, sampling error and costs of this procedure underline the need of non-invasive but sensitive methods of imaging. Several radiopharmaceuticals have been used so far to confirm inflammation: 67Ga, (99m)Tc-nanocolloids and 111In-leucocytes. Scintigraphy with radiolabeled autologous white blood cells (WBCs) is considered a very useful method in identifying sources of inflammation but is difficult to perform and time-consuming.
AIMS: The aim of our study was to investigate whether scintigraphy with (99m)Tc-Anti-Granulocyte BW 250/183 antibody is a valuable diagnostic method in evaluating focal and diffuse inflammation of the heart and could therefore be suggested for use in screening for acute myocarditis.
MATERIAL AND METHODS: A two dimensional scintigraphy and SPECT mode of heart imaging with the use of (99m)Tc-Anti-Granulocyte antibody (740 MBq) was performed on 14 subjects (11 males and 3 females) aged 25-60 years with a positive myocardial biopsy confirming an inflammatory process in the myocardium. After i.v. administration of the tracer a 1 minute series of planar scans was performed within the first 60 minutes. Delayed static scans were performed at 1, 2, 4 and 24 hours.
RESULTS: The scintigraphic scans revealed the uptake of the tracer in the heart area in 13 patients, confirming active inflammatory process. Follow-up scintigraphy was performed 3-5 months after the first study, when the control myocardial biopsy was negative. The results of the study showed the concordance between myocardial biopsy and scintigraphy results in patients with an inflammatory process in the heart.
CONCLUSIONS: Scintigraphy with the use of (99m)Tc-Anti-Granulocyte seems to be a useful diagnostic method in evaluating patients with suspected myocarditis, but further studies are needed to establish its sensitivity and specificity.
Alicja Hubalewska; Dariusz Dudek; Jacek Dubiel; Ewa Płaczkiewicz-Jankowska; Bohdan Huszno; Anna Staszczak; Wiesław Frasik
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Nuclear medicine review. Central & Eastern Europe     Volume:  7     ISSN:  1506-9680     ISO Abbreviation:  Nucl Med Rev Cent East Eur     Publication Date:  2004  
Date Detail:
Created Date:  2005-06-21     Completed Date:  2005-08-11     Revised Date:  2011-10-13    
Medline Journal Info:
Nlm Unique ID:  100886103     Medline TA:  Nucl Med Rev Cent East Eur     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  165-9     Citation Subset:  IM    
Nuclear Medicine Unit, Department of Endocrinology, Institute of Cardiology, Collegium Medicum, Jagiellonian University, Karkow, Poland.
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MeSH Terms
Acute Disease
Antibodies, Monoclonal / diagnostic use*
Mass Screening / methods
Middle Aged
Myocarditis / pathology,  radionuclide imaging*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon / methods*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/BW 250 183; 0/Radiopharmaceuticals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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