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Screening Preeclamptic Cord Plasma for Proteins Associated with Decreased Breast Cancer Susceptibility.
MedLine Citation:
PMID:  24296084     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this protective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and normotensive pregnancies were compared. Umbilical cord plasma samples, depleted of 14 abundant proteins, were subjected to proteomic analysis using the quantitative method of nanoACQUITY ultra performance liquid chromatography-mass spectrometry with elevated energy mode of acquisition(E) (NanoUPLC-MS(E)). Sixty-nine differentially expressed proteins were identified, of which 15 and 6 proteins were only detected in preeclamptic and normotensive pregnancies, respectively. Additionally, expression of 8 proteins (gelsolin, complement C5, keratin type I cytoskeletal 10, pigment epithelium-derived factor, complement factor B, complement component C7, hemoglobin subunit gamma-2 and alpha-fetoprotein) were up-regulated in preeclampsia with a fold change of ⩾ 2.0 when compared to normotensive pregnancies. The identification of alpha-fetoprotein in preeclamptic umbilical cord blood plasma supported the validity of this screen as alpha-fetoprotein has anti-estrogenic properties and has previously been linked to preeclampsia as well as a reduced breast cancer risk. The findings of this pilot study may provide new insights into the mechanistic link between preeclampsia and potentially reduced breast cancer susceptibility in adult life.
Authors:
Hoi Pang Low; Ashutosh Tiwari; Jagadeesh Janjanam; Li Qiu; Chien-I Chang; William C Strohsnitter; Errol R Norwitz; Sun W Tam; James E Evans; Karin M Green; Joao A Paulo; Mats Lambe; Chung-Cheng Hsieh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-29
Journal Detail:
Title:  Genomics, proteomics & bioinformatics     Volume:  -     ISSN:  2210-3244     ISO Abbreviation:  Genomics Proteomics Bioinformatics     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197608     Medline TA:  Genomics Proteomics Bioinformatics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Production and hosting by Elsevier Ltd.
Affiliation:
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
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