| Screening for open neural tube defects. | |
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MedLine Citation:
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PMID: 20638584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal serum screening for congenital anomalies began over 30 years ago with the advent of alpha-fetoprotein (AFP) screening for open neural tube defects. It was from these screening programs that the more complex multiple marker Down syndrome screening programs developed. However, today open neural tube defect screening remains a relatively simple approach. In recent times, questions arise about the validity of the risk assessment associated with neural tube defect screening because of the impact of folate acid enrichment in diets and lack of outcome ascertainment. However, it still remains true that those with elevated AFP levels are at higher risk for having a pregnancy affected with open neural tube defect. |
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Authors:
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David A Krantz; Terrence W Hallahan; John E Sherwin |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-06-15 |
Journal Detail:
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Title: Clinics in laboratory medicine Volume: 30 ISSN: 1557-9832 ISO Abbreviation: Clin. Lab. Med. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100174 Medline TA: Clin Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 721-5 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Biostatistics Department, NTD Labs/PerkinElmer, 80 Ruland Road, Melville, NY 11747, USA. david.krantz@perkinelmer.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Neural Tube Defects / diagnosis* Predictive Value of Tests Pregnancy Prenatal Diagnosis* Risk Assessment alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/AFP protein, human; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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