| Screening of enzyme inhibitors from traditional Chinese medicine. | |
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MedLine Citation:
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PMID: 20883194 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Traditional Chinese medicine (TCM) has been used for more than 4000 years. By comparison with large combinatorial chemistry libraries and natural products of the West for high-throughput screening (HTS) of new drugs discovery, an advantage of TCM is that the preparation has clear efficacies on the therapy of some diseases. Although the effective components are not clear, the clear efficacies of TCM have been identified for long time practice, Therefore, TCMs should be valuable lead compound libraries with a definite therapy efficacy from the viewpoint of HTS. Nevertheless, current HTS technologies are not easily adapted to investigate TCMs because they are designed for screening a relatively pure known chemical at a known concentration. In contrast, TCMs are mixtures of unknown compounds in unknown concentrations that may differ markedly between samples from different plants. This article reviews the current and future researches on the enzyme inhibitors screening from TCM. |
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Authors:
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Yao Shen; Yuming Hu; Bo Chen; Shouzhuo Yao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Combinatorial chemistry & high throughput screening Volume: 13 ISSN: 1875-5402 ISO Abbreviation: Comb. Chem. High Throughput Screen. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810948 Medline TA: Comb Chem High Throughput Screen Country: Netherlands |
Other Details:
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Languages: eng Pagination: 885-99 Citation Subset: IM |
Affiliation:
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Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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