Document Detail

Screening for Down's syndrome in the first trimester: combined risk calculation, methodology, and validation of a web-based system.
MedLine Citation:
PMID:  19330568     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To provide the necessary mathematical formulae to construct a risk calculation package for Down's syndrome using maternal serum free beta human chorionic gonadotrophin, pregnancy associated plasma protein A, and ultrasound nuchal translucency(NT) measurements in the first trimester for use in a web-based system. SETTING: Swedish antenatal screening program. POPULATION: Swedish women choosing to have first trimester screening for Down's syndrome. METHODS: A standard Gaussian approach to calculation of likelihood ratios for each marker value was used following conversion of analyte concentrations and NT measurements to multiples of the normal gestational median (MoM). Validation of the algorithm was carried out on a study group of 3,900 pregnancies (including 29 cases of Down's syndrome). Predicted detection and screen positive rates were compared with an alternative calculation package. MAIN OUTCOME MEASURES: Sensitivity and specificity of screening delivered by risk calculation package. RESULTS: A cut-off risk of 1 in 200 produced a detection rate of 90% at a 4.7% false-positive rate. In addition, use of the calculation package in a web-based system proved efficient in routine practice, providing rapid access by individual centers to results and easy central monitoring and auditing of the program. CONCLUSIONS: The system described here fulfills the requirement for an appropriately validated risk calculation package, is fully user configurable with easy access through a web-based system allowing extension of the screening program to multiple centers.
Marius Kublickas; Jennifer Crossley; David Aitken
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  88     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-06-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  635-8, 7p following 638     Citation Subset:  IM    
Centre of Fetal Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
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MeSH Terms
Biological Markers / blood
Chorionic Gonadotropin, beta Subunit, Human / blood
Congenital Abnormalities / ultrasonography
Down Syndrome / blood,  diagnosis*,  ultrasonography
Genetic Testing / methods
Mass Screening / methods*
Models, Biological
Nuchal Translucency Measurement
Predictive Value of Tests
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / analysis
Prenatal Diagnosis
Risk Assessment
Ultrasonography, Prenatal
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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